Mission
The MacMillan Center for the Study of the Non-Coding Cancer Genome is undertaking this grand challenge of decoding the causality of the non-coding genome and epigenome in cancer. Our research teams investigate which elements of the non-coding genome contribute to stable states of gene expression and drug resistance and what molecular factors govern the formation drug resistance in cancer.
The MacMillan Center has organized its collaborative scientific approach to address two overarching goals: 1) understanding how, when, and why cancers acquire memory of treatment exposure and cellular states and 2) incorporating non-coding genome features into cancer therapeutics and diagnostics
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The non-coding or “dark” genome determines the gene expression states that define cell types, and the cell type of origin has a strong influence in cancer progression, metastasis, and therapeutic resistance. Learning how and why memory of cancer states forms would enable approaches to prevent or disrupt cancer evolution. The fundamental mechanisms in which cancers acquire memory likely involve deep connections between genomic variation, mutational processes, and the capacity of the non-coding genome to determine phenotypic states of tumors.
Our research teams seek to 1) measure and identify the mechanics of how cancers acquire memory of treatment exposure and fitness states and 2) predict and intervene in future memory resistance states through multi-mode causal inference models
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By addressing the fundamental mechanisms by which cancer phenotypes are selected and treatment resistance is acquired, interventions which block or reverse cell state by targeting non-coding genome features could be designed for therapeutic benefit. Furthermore, access to cancer samples and data from patients with differing ancestry can enable broader clinical impact.
Our research teams seek to 1) understand the role of the non-coding genome in the biology of cancer phenotypes from individuals with different genetic ancestry and 2) detect therapeutic response and block memory formation using features of the non-coding genome and epigenome.
Aims
Community
We are committed to fostering a workplace environment that is welcoming and fair to all, ensuring that every employee has the opportunity to thrive. We believe that bringing together individuals with diverse backgrounds, experiences, and perspectives leads to greater collaboration, innovation, and discovery. Valuing and supporting each employee in reaching their full potential strengthens our organization and enhances our collective success.